공지사항

커뮤니티

Home :: 커뮤니티 :: 공지사항

공지사항

  • 관리자 (sinbio)
  • 2019-02-21 10:56:00
  • hit100
  • vote0
  • 106.240.248.210

 위
1.위산 분비 억제 작용이 있다
2.항 헬리코박터 파이로니 작용이 있다.
1)"Effects of the tissue cultured and cultivated ginseng on gastric secretion and pepsin activity were investigated. Fifty percent ethanol extracts of both cultured and cultivated ginsengs reduced gastric secretion and acid output in pylorus-ligated rats. They did not affect pepsin activity…. These results suggest that both tissue cultured and cultivated ginsengs may have an inhibitory effect on gastric secretion. The effect seems to be due to the inhibition of acid secretion via the central nervous system."
경작되거나 조직 배양된 인삼이 위액 분비나 펩신 작용에 대한 효능을 연구하였다.양 인삼의 50% 에탄올 추출물은 유문이 결찰 된 쥐에서 산 방출 및 위액 분비를 감 소 시켰으나 펩신 작용에는 효과가 없었다. 이 결과는 양 인삼이 위액 분비에 억제적 효과를 지닌 것으로 보이며 중추신경을 경유하여 산 분비를 억제하는 효과로 추측된다.
         문헌 
1.Arch Pharm Res. 2001 Aug;24(4):297-9.
In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng.
Bae EA, Han MJ, Baek NI, Kim DH.
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
This study investigated the effect that some polyacetylenes and protopanaxatriol, which were isolated from heated ginseng (family Araliaceae), have on inhibiting Helicobacter pylori (HP) growth. Among the compounds tested, panaxytriol was quite effective in inhibiting HP growth with an MIC of 50 microg/ml. Ginsenoside Rh1 and protopanaxatriol weakly inhibited H?ATPase from a rat stomach.
실험관 내 실험에서 인삼으로부터 분리한 PPT의 항 헬리코박터 파이로리 작용
이 연구는 인삼을 열처리하여 얻어진 polyacetylene과 PT가 헬리코박터 파이로리의 성장에 대한 억제효과에 대한 탐구이다.  실험된 물질 중에서 PT가 MIC 50 microg/ml에서 가장 효과적이었고 Rh1과 PPT는 약하게 억제하였다.
PMID: 11534760 [PubMed - indexed for MEDLINE]
2.Arch Pharm Res. 2003 nov;26(11):906-11.
Ginsenoside Rb1: the anti-ulcer constituent from the head of Panax ginseng.
Jeong CS, Hyun JE, Kim YS.
College of Pharmacy, Duksung Womens University, 419 Ssangmun-dong, Dobong-ku, Seoul 132-714, Korea. choonsik@duksung.ac.kr
We previously reported that the butanol (BuOH) fraction of the head of Panax ginseng exhibited gastroprotective activity in peptic and chronic ulcer models. In order to identify the active constituent, an activity-guided isolation of the BuOH faction was conducted with a HCl x ethanol-induced gastric lesion model. The BuOH fraction was passed through a silica-gel column using a chloroform-methanol gradient solvent system, and six fractions (frs. 1-6) were obtained. The active fr. 5 was further separated by silica-gel column, to yield 6 subfractions (subfrs. a-f). Subfr. d was composed of ginsenosides Re, Rc and Rb1. The most active constituent was ginsenoside Rb1 (GRb1), a protopanaxadiol glycoside, which was investigated for its anti-ulcer effect. Gastric injury induced by HCl x ethanol, indomethacin and pyloric ligation (Shay ulcer) was apparently reduced with oral GRb1 doses of 150 and 300 mg/kg. GRb1 at these dosage significantly increased the amount of mucus secretion in an ethanol-induced model. The anti-ulcer effects were consistent with the result of histological examination. These results suggest that the major active constituent in the head of Panax ginseng is GRb1, and that anti-ulcer effect is produced through an increase in mucus secretion.

3.Aug;24(4):297-9.
In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng.
Bae EA, Han MJ, Baek NI, Kim DH.
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea.
This study investigated the effect that some polyacetylenes and protopanaxatriol, which were isolated from heated ginseng (family Araliaceae), have on inhibiting Helicobacter pylori (HP) growth. Among the compounds tested, panaxytriol was quite effective in inhibiting HP growth with an MIC of 50 microg/ml. Ginsenoside Rh1 and protopanaxatriol weakly inhibited H+/K+-ATPase from a rat stomach. 

 

게시글 공유 URL복사
댓글작성

열기 닫기

댓글작성